Antabuse (disulfiram) blocks an enzyme that is involved in metabolizing alcohol intake. Disulfiram produces very unpleasant side effects when combined with alcohol in the body. Antabuse is used in certain people with chronic alcoholism. This medicine can help keep you from drinking because of the unpleasant side effects that will occur if you consume alcohol while taking Antabuse. Antabuse is used together with behavior modification, psychotherapy, and counseling support to help you stop drinking. You should not use Antabuse if you have recently taken metronidazole or paraldehyde, or if you have consumed any foods or products that contain alcohol (mouthwash, cough medicine, cooking wine or vinegar, certain desserts, and others). Antabuse should never be given to a person without his or her knowledge of taking the medicine. Do not take Antabuse if you have consumed alcohol within the past 12 hours. 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Antabuse Antabuse, also known by its scientific name disulfiram, medication was approved by the U. S. Food and Drug Administration 1 USDA in 1951 for the treatment. This medication must be prescribed by a physician and cannot be given to anyone with a history of severe heart disease, psychosis, allergy to antabuse. A 42-year-old male developed psychotic symptoms 3 weeks after initiating treatment with disulfiram for alcohol dependency. The patient had a history of chronic.