Tamoxifen bone density

Discussion in 'Canadadrugs' started by GIVI, 25-Aug-2019.

  1. galgal Well-Known Member

    Tamoxifen bone density


    This happens gradually over time but is much more significant after the menopause. Around the age of 35 we start to lose bone density as part of the natural ageing process. Back to top Our bones increase in density and strength until we reach our late 20s. Although osteoporosis cannot be cured, treatments are available to try to keep the bones strong and less likely to fracture. The most common sites for a fracture to occur are the wrist, hip and back (spine). Generally, osteoporosis causes no pain or symptoms, so often a person won’t realise they have the condition until a fracture happens. These fractures are often described as ‘fragility fractures’. Treatments used for breast cancer can increase the risk of developing osteoporosis. This page discusses how this might happen and provides information on the effects of chemotherapy, Tamoxifen and Aromatase inhibitors on bone. There is also information on the benefits of diet and weight bearing exercise to help with bone strength if you also are being treated for breast cancer. Women who have had breast cancer may be at increased risk of developing osteoporosis: the loss of bone strength, making bones more fragile and prone to fracture. If you have been diagnosed with breast cancer, you should ask your doctor to check your bone health, especially if you have other risk factors for osteoporosis such as a family history, low calcium intake and/or low vitamin D levels. Two measures of bone health are important to consider: Women with breast cancer have an increased risk of developing osteoporosis because of the treatments used in breast cancer. Treatments can impact directly on oestrogen levels (vital for bone strength), and may also cause ovarian failure in premenopausal women, resulting in a further significant fall in oestrogen and a premature/early menopause.

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    Tamoxifen for breast cancer usually only reduces bone density by a small amount. In postmenopausal women, aromatase inhibitors increase bone loss at an average rate of 1 to 3% per year. Topic Tamoxifen and Bone Density Forum Hormonal Therapy - Before, During, and After — Risks and benefits, side effects, and costs of anti-estrogen medications. Note Please remember that there are good experiences and bad with ALL treatments and this is a safe place to share YOUR experience, not to be influenced or influence others. All aromatase inhibitors can cause bone loss. Tamoxifen can be used to treat both pre and postmenopausal women. Tamoxifen lowers bone density only in.

    uses cookies to improve performance by remembering your session ID when you navigate from page to page. Please set your browser to accept cookies to continue. This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website. Your risk of osteoporosis (bone thinning) can be affected by breast cancer treatment and other treatments that lower your oestrogen levels. Osteoporosis is thinning of the bones so that they become more brittle. Our bones start to thin after the age of 35 or so, as part of the natural ageing process. Any cancer treatment in women that lowers oestrogen levels can increase the risk of osteoporosis. These treatments include: Tamoxifen for breast cancer usually only reduces bone density by a small amount. In postmenopausal women, aromatase inhibitors increase bone loss at an average rate of 1 to 3% per year. In young women who have had ovarian suppression followed by aromatase inhibitor therapy, bone density is lost at an average of 7 to 8% per year. Treatment with tamoxifen for 2 to 5 years before having aromatase inhibitors may slow down the rate of bone loss. Women who have had an early menopause (before the age of 45) due to cancer treatment or who have ovarian suppression therapy and aromatase inhibitors are at higher risk of bone loss.

    Tamoxifen bone density

    PREVENTION OF BONE LOSS AFTER WITHDRAWAL OF TAMOXIFEN, Breast Cancer Topic Tamoxifen and Bone Density

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  5. Osteoporosis is usually diagnosed using a bone density scan, often referred to as a DEXA dual energy x-ray absorptiometry or DXA scan. A DEXA scan is used to measure bone mineral density BMD. BMD is the amount of calcium and other minerals in an area of bone and is a measurement of bone strength.

    • Bone health and osteoporosis - Breast Cancer Care.
    • Bone health and breast cancer - Breast Cancer Network Australia.
    • Breast cancer and osteoporosis.

    The women were followed for 2 years. Women receiving tamoxifen increased lumbar spine BMD 0.61% per year but lost BMD at the 33% radial site at a rate of 0.88% per year. The women not receiving tamoxifen lost BMD at both sites at a rate of 1.29% at the radius and 1% at the spine. Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women. Premenopausal women treated with chemotherapy often develop early menopause and thus, enter a period of accelerated bone loss. We conducted a prospective study of the effect of sequential adjuvant therapy with chemotherapy followed by tamoxifen on bone mineral density

     
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