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  8. inductor Well-Known Member

    CELLULOSE, MICROCRYSTALLINE / ETHYLCELLULOSES / TRIETHYL CITRATE / HYPROMELLOSES / POLYETHYLENE GLYCOL 6000 / TITANIUM DIOXIDE / METHACRYLIC ACID - ETHYL ACRYLATE COPOLYMER (1:1) TYPE A / TALC / CROSCARMELLOSE SODIUM / SODIUM STEARYL FUMARATE / SILICON DIOXIDE / WATER 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information from clinical trials does, however, provide a basis for identifying the adverse events that appear to be related to drug use and for approximating rates. In the MERIT-HF study comparing metoprolol succinate extended-release tablets in daily doses up to 200 mg (mean dose 159 mg once-daily; n=1990) to placebo (n=2001), 10.3% of metoprolol succinate extended-release tablets patients discontinued for adverse reactions vs. The table below lists adverse reactions in the MERIT-HF study that occurred at an incidence of ≥ 1% in the metoprolol succinate extended-release tablets group and greater than placebo by more than 0.5%, regardless of the assessment of causality. In a randomized, double-blind, placebo-controlled trial of 8351 patients with or at risk for atherosclerotic disease undergoing non-vascular surgery and who were not taking beta–blocker therapy, metoprolol succinate extended-release tablets 100 mg was started 2 to 4 hours prior to surgery then continued for 30 days at 200 mg per day. Metoprolol succinate extended-release tablets use was associated with a higher incidence of bradycardia (6.6% vs. 2.4%; HR 2.74; 95% CI 2.19,3.43), hypotension (15% vs. 9.7%; HR 1.55; 95% CI 1.37,1.74), stroke (1.0% vs 0.5%; HR 2.17; 95% CI 1.26,3.74) and death (3.1% vs 2.3%; HR 1.33; 95% CI 1.03, 1.74) compared to placebo. Metoprolol Succinate Extended-Release Tablets - USP-NF Alphabetical Pill Identification - View Index M - NDC List Metoprolol tartrate Pill Images - What does Metoprolol tartrate look.
     
  9. Statrega Well-Known Member

    Pliva is a Croatian pharmaceutical company headquartered in Zagreb. In the late 1970s, a team of Pliva’s researchers discovered an antibiotic named Azithromycin. From early trials, Azithromycin proved to be extremely efficient and capable of remaining in the body tissue of animals longer than other similar antibiotics. Many years of research led Pliva to the development of a valuable drug with huge therapeutic and business potential. At the time, however, Pliva was a small player relative to the leading global pharmaceutical firms and lacked the necessary capital to commercialize the product internationally and reap the full benefit of its successful research. In 1981, Pliva filed a patent application for Azithromycin in the former Yugoslavia and subsequently patented it worldwide, including in the United States when the drug was still undergoing trials before its final approval by the relevant health authorities. Patenting proved to be the key to the commercial success of Azithromycin: scientists from pharmaceutical multinational Pfizer Inc. Zithromax Tablets, 250 Mg, 500 Mg Information from Azithromycin - Side Effects, Uses, Dosage, Overdose, Pregnancy. Macrolides - GlobalRPH
     
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