Last week, the FDA issued a Drug Safety Communication to warn that use of popular painkillers can significantly increase a person’s risk of heart attack or stroke. Now, a study released earlier this week shows that individuals who combine NSAIDs with antidepressants may be raising … Full Story Right now, the drug maker Pfizer is facing several hundred lawsuits brought by plaintiffs who claim that the company failed to warn of serious Zoloft birth defects risks. Now, evidence presented in a Philadelphia Zoloft birth defect lawsuit may cause significant problems for the embattled … Full Story A recent study has drawn a correlation between use of SSRI antidepressants by pregnant women and a heightened likelihood that their babies will show signs of autism. The study, by researchers from the Bloomberg School of Public Health, evaluated 966 pairs of mothers and their … Full Story The state of Louisiana has brought a lawsuit against Pfizer, makers of the bestselling antidepressant drug Zoloft, claiming the company engaged in grossly fraudulent marketing by paying prominent medical researchers to publish articles written by Pfizer, praising Zoloft. On February 26, 2009 the Food and Drug Administration announced that manufacturers of metoclopramide (REGLAN), a drug used to treat gastrointestinal disorders, must add a boxed warning about the risk of long-term or high-dose use, which has been linked to tardive dyskinesia, a condition which may include involuntary and repetitive movements of the body, even after the drugs is no longer taken. Children and adults with gastroesophageal reflux (GER) and gastroesophageal reflux disease (GERD), diabetic gastroparesis, and other related conditions are often prescribed Reglan. Other risks are associated with Reglan For whom is Reglan NOT an appropriate treatment? Post-operative patients and those undergoing cancer treatments may be given Reglan to reduce nausea and vomiting. Reglan and tardive dyskinesia How is Reglan-induced tardive dyskinesia treated? Reglan (metoclopramide) is a prescription drug used to treat gastrointestinal problems in children and adults. Infants are commonly given Reglan to treat GER and GERD. Reglan is a dopamine antagonist that increases lower esophageal sphincter pressure and improves gastrointestinal emptying. The FDA approved Reglan, which is manufactured by Baxter Healthcare Corporation, for short-term treatment (between 4 and 12 weeks) of these conditions only after conservative methods of treatment have failed. However, evidence shows that one-third of patients are prescribed Reglan for longer than 12 weeks, which is against FDA recommendations. 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