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    Isotretinoin (brand name Roaccutane) can have serious side effects and its use must be supervised by a dermatologist. It's reserved for treating severe acne (such as nodular or conglobate acne or acne at risk of permanent scarring) that hasn't improved with standard treatment involving oral antibiotics and topical medicines. Isotretinoin belongs to a group of medicines known as retinoids, which are derivatives of vitamin A. Isotretinoin taken by mouth works by reducing the production of the skin's natural oil (sebum). Acne occurs due to an excessive production of sebum from over-active sebaceous glands in the skin. The sebum blocks the sebaceous glands, which prevents the oil from flowing freely out and causes an accumulation of sebum under the skin. The bacteria associated with acne thrive in these conditions. Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane or Roaccutane), is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 1–4 months), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in-utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.

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    This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. " July 8, 2009 -- Accutane won't be sold any more, drug giant Hoffmann-La Roche Inc. Generic versions of the acne drug, called isotretinoin, are still available from several manufacturers. But Roche, which has sold the drug to 13 million patients since 1982, will not be one of them. The decision was made for "business reasons," Roche announced in a news release. Those reasons include declining sales: Accutane sales now make up less than 5% of the isotretinoin market. Another big reason: Personal injury lawsuits, which Roche is aggressively defending. But yes, will keep it short (time again is a scarce resource! Till I get time to write a long boring post for you all – enjoy these awesome ads. So thought something is better than nothing and hence this post. And yes, don’t forget to tell us which one you liked the most.

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